Simvastatin side effects
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Agency for the United States Food and Drug Administration (FDA) issued a warning relating to use of cholesterol-lowering drugs in high doses.
The FDA said in its official announcement, the consumption of high doses of cholesterol drugs simvastatin (generic name) may increase the risk of muscle damage (myopathy) and potentially cause interference in the kidneys. This warning also was also a recommendation to the doctors to be more cautious in prescribing high doses of cholesterol drugs.
The FDA said patients using doses of 80 milligrams of Zocor or generic brand drug simvastatin had a higher risk than those who use it in low doses, or drugs other than statins.
Dose of 80 milligrams should be used only for patients who never use more than one year without any symptoms of injury. For new patients, the FDA said, suggested therapy began treatment with lower doses. FDA-approved dose for this drug use 5 to 80 milligrams.
FDA data show, more than 2.1 million patients in the United Serkat were prescribed Zocor, or simvastatin in the past year. Pharmaceutical company which manufactures Zocor, Merck, said that about 12 percent of patients currently using this drug in high doses.
"This is an important treatment for these patients because of their high risk of heart disease. These patients should not stop treatment on his own. They should consult with a doctor," said Dr. Michael Rosenblatt, chief medical officer of Merck.
Patients who overdose, the FDA said, may experience muscle injury called myopathy, which is a pain, weakness, and increased muscle enzyme called creatine kinase. The most serious result of myopathy, called rhabdomyolysis, can cause fatal injury to the kidney. This condition is rare, and only affects about 5 of every 100,000 patients taking Zocor for one year.
"The drug types other statins, like Lipitor (atorvastatin) and Crestor (rosuvastatin), capable of lowering cholesterol with the risk of muscle injury is lower," said Dr. Gregg C. Fonarow, a professor of cardiology at the University of California at Los Angeles.
He added, "Patients should reconsider and take the opportunity to discuss with your doctor. Ask your doctor which type of statin therapy are most appropriate in improving the quality of healthcare.
The FDA said in its official announcement, the consumption of high doses of cholesterol drugs simvastatin (generic name) may increase the risk of muscle damage (myopathy) and potentially cause interference in the kidneys. This warning also was also a recommendation to the doctors to be more cautious in prescribing high doses of cholesterol drugs.
The FDA said patients using doses of 80 milligrams of Zocor or generic brand drug simvastatin had a higher risk than those who use it in low doses, or drugs other than statins.
Dose of 80 milligrams should be used only for patients who never use more than one year without any symptoms of injury. For new patients, the FDA said, suggested therapy began treatment with lower doses. FDA-approved dose for this drug use 5 to 80 milligrams.
FDA data show, more than 2.1 million patients in the United Serkat were prescribed Zocor, or simvastatin in the past year. Pharmaceutical company which manufactures Zocor, Merck, said that about 12 percent of patients currently using this drug in high doses.
"This is an important treatment for these patients because of their high risk of heart disease. These patients should not stop treatment on his own. They should consult with a doctor," said Dr. Michael Rosenblatt, chief medical officer of Merck.
Patients who overdose, the FDA said, may experience muscle injury called myopathy, which is a pain, weakness, and increased muscle enzyme called creatine kinase. The most serious result of myopathy, called rhabdomyolysis, can cause fatal injury to the kidney. This condition is rare, and only affects about 5 of every 100,000 patients taking Zocor for one year.
"The drug types other statins, like Lipitor (atorvastatin) and Crestor (rosuvastatin), capable of lowering cholesterol with the risk of muscle injury is lower," said Dr. Gregg C. Fonarow, a professor of cardiology at the University of California at Los Angeles.
He added, "Patients should reconsider and take the opportunity to discuss with your doctor. Ask your doctor which type of statin therapy are most appropriate in improving the quality of healthcare.
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